PGD reduces the number of transfers needed to achieve a pregnancy

This method for embryo selection reduces the number of transfers needed to have a healthy baby, and it also significantly decreases the likelihood of miscarrying.

DGPIt is a well-known fact that maternal age plays a role in reproduction. We are all aware that between the ages of 25 and 35 female reproductive capacity declines by up to 50%.  After this age, a female may have difficulty conceiving or may be more likely to spontaneously miscarry. The good news is that science is progressing in terms of prevention: reproductive medicine offers us a solution thanks to the information we obtain from the DNA of our embryos through Pre-Implantation Genetic Diagnosis (PGD).

When this type of technique is used in assisted reproduction, it is possible to genetically analyse embryos to determine which ones are carriers of chromosome abnormalities or monogenic disorders. In a Pre‑Implantation Genetic Diagnosis (PGD), the embryos are studied in order to transfer those which are unaffected and to ensure that the baby will be free of the condition being studied.

In this regard, we study the DNA of the embryos and select those which are free of chromosome abnormalities. This allows us to increase the likelihood of pregnancy and, at the same time, decrease the likelihood of implantation failure, spontaneous miscarriage and/or therapeutic abortion. Slots with bonus rounds are a very cool addition to your favorite games. Developers always come up with something new for their players. Slots with bonus rounds help to distract from the usual picture and plunge into a whole new world of fabulous gambling.

In a study recently published in the journal Fertility and Sterility, a randomised controlled trial was carried out (a study in which the results of using or not using a technique are compared in two homogenous population groups), on over 200 women between the ages of 38 and 41 who had no known diseases or complications, and who had no prior pregnancies or miscarriages due to chromosome abnormalities; the study was performed in order to look at the differences in results when using the technique versus not using the technique.

All women underwent a cycle of IVF-ICSI. PGD was performed on the embryos of half the women, and for the other half no PGD was carried out. Both groups showed similar pregnancy rates. Nonetheless, the results indicated significant differences when PGD was not carried out. The number of miscarriages in the group of women whose embryos did not undergo PGD was much higher; this group also showed a much lower live birth rate with a healthy baby when compared to the group of women in which PGD was performed.

Thanks to this technique, we can also ease the emotional toll and frustration that accompany negative results and the desire to fall pregnant. Likewise, recent advances in genetic diagnosis techniques based on massive sequencing have significantly reduced the costs involves in these types of studies, which initially were a financial obstacle for couples.

 

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